Is Semaglutide Safe and Effective for Weight Loss?

in Body Sculpting, Semiglutide, Weight Loss April 20, 2023

Semaglutide lowers blood sugars independently of its effect on weight, but its ability to help individuals lose weight has made it appealing to non-diabetics as well as diabetics. Essentially, it makes you eat less, though the exact mechanism isn’t clear. The medication, however, keeps the stomach full for longer, which reduces appetite. Semaglutide also affects gut bacteria, which can help with weight loss and trials of this class of medication have shown it can help users shed 10% to 15% of their total body weight.

How Does Semaglutide Work?

Semaglutide and other GLP-1 medications mimic the function of a hormone called glucagon-like peptide 1. In response to the rise in blood sugar you experience after eating a meal, GLP-1 receptor agonists help the body produce more insulin to keep those blood sugar levels from spiking.

There are GLP-1 receptors in the brain which when stimulated leads to a decrease in food intake. There are also GLP-1 receptors in the gut which when stimulated leads to a delay in gastric emptying. GLP-1 agonists stimulate these GLP-1 receptors and lead to weight loss in two main ways – decreased gut motility and decreased appetite.


Semaglutide medications work for many people, but your results may not be the same as someone else’s. Weight loss from semaglutide is due to an overall decrease in one’s intake of calories from food and drink. The less calories you consume, the more weight you lose. On average, those taking semaglutide may lose between 10-15% of their total body weight.

Safety and Possible Side Effects

Before you start Semaglutide, it’s important to know what the possible side effects could be. Semaglutide has been approved by the FDA because this medication and others like it have been found to be safe during clinical studies. However, every medical intervention brings the potential for side effects, and it has some drawbacks. The most common side effects of semaglutide medications include:

Starting at a lower dose and slowly increasing the dosage could help ward off some of these common side effects. Make a free consultation appointment with the Uptown Medispa near you to explore if Semaglutide is right for you.


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